Tell a doctor straight away if you:. Pediatric Nephrology. Clinical Pharmacology and Therapeutics. Allopurinol can make you feel sleepy. This medication may be Allopurinol for other uses; ask your doctor or pharmacist for more information. For this reason, oxipurinol is believed responsible for the majority of allopurinol's effect. Only stop taking allopurinol if a doctor tells you to. It is important for you to keep a written list of all of the prescription and nonprescription over-the-counter medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. But drinking alcohol increases the level of uric acid in your blood and can trigger an attack of gout. Allopurinol is not suitable for certain people. Sign up now. You can do a lot of prep work to make the perfect sleep environment. The following symptoms are uncommon, but if you experience any of them, call your doctor immediately: skin rash painful urination blood in the urine irritation of the eyes swelling of the lips or mouth fever, sore throat, chills, and other signs of infection loss of appetite unexpected weight loss itching Allopurinol may cause other side effects. However, talk to a doctor first if you want to try for a baby while taking allopurinol. Visit your doctor regularly. Alloourinol also: Allopurinol drug interactions in more detail. Arthritis Rheum. You may need to follow a special diet while using allopurinol. If your child is sick less than 20 minutes after having a dose of allopurinol, give them the same dose again. You could also ask a pharmacist for advice on ways to help you remember to take your medicines. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome. Instead, the best way to dispose of your medication is through a medicine take-back program. Q: I've been prescribed allopurinol. You may need to lessen your intake of animal protein, sodium, refined sugars, or foods rich in oxalate and calcium, especially if you have kidney stones that keep coming back. Adverse Effects Allopurinol is a relatively safe medication, although adverse effects can occur. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Common allopurinol side-effects these affect less than 1 in 10 people. If you have repeat kidney stones, your doctor may tell you to eat a special diet. StatPearls [Internet]. Vasc Health Risk Manag. Tophus regression was not reported sufficiently to calculate group differences. Colchicine may be used to prevent attacks of pseudogout. Mayo Clinic does not endorse any of the third party products Allopurinol services advertised. Drug information provided by: IBM Micromedex. Allopurinol, therefore, decreases uric acid formation and may also inhibit purine synthesis. The amount of medicine that you take depends on the strength of the medicine. The primary source for the information in this leaflet is the. This is a decision you and your doctor will make. Gout is a form of arthritis, causing intensely painful, red, hot and swollen joints often the big toe. Concurrent diuretics, especially thiazide use, renal insufficiency stage 3 or higher are major risk factors. Patients shall be counseled about the signs and symptoms of AHS with a recommendation to discontinue allopurinol promptly if they develop skin rash concerning AHS especially early in therapy. Clinical Pharmacology and Therapeutics. Call our helpline Taking allopurinol with painkillers You can take allopurinol with paracetamol and anti-inflammatory medicines such as ibuprofennaproxenor indomethacin. However, some cancer treatments can cause changes in the blood which can be made worse if you take allopurinol. A high uric acid level can cause gout or gouty arthritis joint pain and inflammation. Call your doctor for medical advice about side effects. Allopurinol interacts with the drugs azathioprine and mercaptopurine. Selection criteria:. This helps the crystals to dissolve and stops attacks of gout. The tablet should be swallowed with water. Seminars in Hematology. Background: what is chronic gout and what is allopurinol?
Allopurinol - necessary phrase Your Allpourinol may prescribe another medication such as colchicine to prevent gout attacks for the first few months you take allopurinol. If this happens, discuss Allopurijol with your doctor at your next visit. Avoid driving or hazardous activity until you know how allopurinol will affect you. Your doctor may recommend other gout medication to take at this time. Never give it to anyone else, even if their condition appears to be the same, as this could do harm. In other projects Wikimedia Commons. To reduce your risk of kidney stones forming, drink 8 to 10 full glasses of fluid every day, unless your doctor tells you otherwise. Only one trial was at low risk of bias in all domains. Pain, function and tophus regression were not reported in sufficient detail to present results. Sometimes starting allopurinol can actually trigger an attack of gout, as the crystals begin to dissolve. Common side effects when used by mouth include itchiness and rash. The information may differ from that provided by the manufacturer. World Health Organization. Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Allopurinol is used to treat gout or kidney stonesand to decrease levels of uric acid in people who are receiving cancer treatment. This can happen months or years after treatment is started. If you aren't tolerating allopurinol and show any side effects, you should contact your doctor. Keep the medicine tablets in a cupboard, away from heat and direct sunlight. Allopurinol and mortality in hyperuricaemic patients. Liquid medicine: Measure out the right amount using an oral syringe or medicine spoon. Tablets should be swallowed with a glass of water, milk or juice. Page last reviewed: 21 November Next review due: 21 November A single copy of these materials may be reprinted for noncommercial personal use only. For a full list, see the leaflet inside your medicines packet. Allopurinol does not affect any type of contraception including the combined pill or emergency contraception.
Allopurinol is an arthrifuge which inhibits xanthine oxidase and prevents formation of uric acid, from xanthine and hypoxanthine. Reduces the concentration of uric acid and its salts in body fluids, promotes the dissolution of existing urate deposits and prevents their formation in tissues and kidneys. The medication is used to treat diseases accompanied by hyperuricemia: gout (primary and secondary), nephrolithiasis (forming of kidney stones from urates); hyperuricemia (abnormally high level of uric acid in blood, both primary and secondary), which results in diseases involving enhanced dissolution of nucleoproteins and elevated levels of uric acid in the blood, including at various forms of leukemias, and also for treatment of some other conditions.
Dosage and direction
The dose of 100-800 mg a day may be prescribed depending on the condition. Initial dose of 100 mg can be increased gradually. Patients with acute gout and tophi (uric acid crystals in the tissues mostly around joints) should be treated with 300-400 mg of Allopuionol daily. Doses over 300 mg should be divided in two or more intakes. Take medication with food to avoid irritation of the stomach. Do not take large doses of vitamin C. Drink plenty of water to avoid formation of kidney stones. Limit consummation of alcoholic beverages and purine-rich foods such as sweetbreads, sardines, anchovies, kidneys, liver, and lentils.
Allopurinol should be taken over a period of several months so your symptoms start to reduce. Regular intake is important even no immediate effect is noticed. You may experience acute attacks of gout more often at the beginning of treatment with Allopurinol even after normal uric acid levels are reached. The attacks will become shorter and less acute as the therapy continues. At any sign of allergic reaction stop taking the medication and consult your doctor as development of serious skin disease, irreversible damage to the liver, or generalized inflammation of a blood or lymph vessel is possible in some individuals. Inform your doctor if you have diabetes or kidney dysfunction before to take Allopurinol as correction of your dose is needed.
Allopurinol cannot be used in patients with hypersensitivity to the medication, in individuals with a hepatic or renal disorders, primary hemochromatosis, asymptomatic hyperuricemia, acute gout, pregnancy, lactation. The medication cannot be prescribed to children under 14 years of age unless the patients are treated for leukemia, malignant tumors and enzymatic disorders. C care. Renal failure, heart failure, diabetes mellitus, hypertension.
Possible side effect
The most common adverse reactions are diarrhea, nausea, allergy (rash, itching), and drowsiness. Stop taking the medication at first signs of rash, painful or bloody urination, eye irritation, or facial swelling, because these can be signs of a severe allergic reaction requiring immediate treatment. In rare cases Allopurinol can cause damage to nerve, kidney, and bone marrow as well as be a reason to a serious and even fatal allergic liver toxicity. In patients with liver toxicity appetite loss and itching may witness about it. The risk increases in patients with kidney impairment.
The dose of oral mercaptopurine (Purinethol) and azathioprine (Imuran) should be reduced as Allopurinol increases their blood levels. Risk of skin rash increases in patients taking Allopurinol with penicillins.
Take the missed dose as soon as you remember unless it is almost time of your next dose. If it is almost time of your next dose just skip it and return to your regular scheme. Do not exceed the recommended dose.
In case of suspected overdose seek for immediate medical attention. No specific information is available about Allopurinol overdose.
Store at room temperature, below 25 C (77 F) and out of reach and children and pets.
We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis.All specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.