For Caregivers. The information contained in this website is meant to be helpful and educational, but is not substitute for medical advice. Cytoaxn your health care provider within 24 hours of noticing any Cytoan the following: Nausea interferes with ability to Cytoxn and unrelieved with prescribed medication Vomiting vomiting more than Cytoxan in a hour period Diarrhea episodes in a hour period Unusual bleeding or bruising Black or tarry stools, or blood in your stools Blood in the urine Pain or burning with urination Extreme fatigue unable to carry on self-care activities Mouth sores painful redness, swelling or ulcers Always inform your health care provider if you experience any unusual symptoms. Do not receive any kind of immunization or vaccination without your doctor's approval while taking cyclophosphamide. It is usually given through a vein by injection or infusion intravenous, IV or by mouth in tablet form, depending upon diagnosis. The faster the cells are dividing, the more likely it is that chemotherapy will kill the cells, causing the tumor to shrink. Cancer Research. Drug Status. If you're pregnant or become pregnant, talk to your doctor about alternatives to Cytoxan. Ctoxan Pharmacokinetics. Insights from three cases complicating Cyotxan Cytoxan. Clin Breast Cancer. Cyclophosphamide is used for severe complications of lupussystemic sclerosis sclerodermasome forms of vasculitis Cytosan, myopathiessuch as polymyositis and dermatomyositis; and sometimes Cytocan arthritis. Chemotherapy drugs that affect cells when they are at rest are called cell-cycle non-specific. Clinical Oncology. This information is provided for general education only. Cyclophosphamide Prescribing Information. There may also be increased risks for other kinds of cancer, but the risks are less high. Drug Class. ALDHs protect these actively proliferating tissues against toxic effects of phosphoramide mustard and acrolein by converting aldophosphamide to carboxycyclophosphamide that does not give rise to the toxic metabolites phosphoramide mustard and acrolein. At some centers experienced in the care of patients with vasculitis and the use of cyclophosphamide, blood counts are checked every 2 weeks. The ability of chemotherapy to kill cancer cells depends on its ability to halt cell division. Pharmacological Reviews. Merriam-Webster Cytocan. Different Cytooxan may affect different parts of the body. Frequency not reported : Agranulocytosis, lymphopenia, hemoglobin decreased [ Ref ]. The Journal of Pharmacology and Experimental Therapeutics. From Wikipedia, the free encyclopedia. Cyclophosphamide can be given by a number of different routes. Get plenty or rest. Annales Francaises d'Anesthesie et de Reanimation in French. Availability Discontinued. Archived from the original on 25 April Some of the dosage forms listed on this page may not apply to the brand name Cytoxan. Avoid contact sports or activities that could cause injury. Because Cytoxan can irritate the bladder, patients should drink at least quarts of water every 24 hours, unless instructed Cutoxan. The ability of chemotherapy to kill cancer cells depends on its ability Cytoxn halt cell division. Clinical Pharmacokinetics. It appears to be an alternative to the more traditional treatment with melphalan in people who are ill-suited for autologous stem cell transplant. Journal of the American Chemical Society. Because of its impact on the immune system, it is used in animal studies. Monitoring and Testing While Taking Cyclophosphamide You will be checked regularly by your doctor while you are taking cyclophosphamide, to monitor side effects and check your response to therapy. For information about the 4th Angel Mentoring Program visit www. Other uses for this medicine. Frequency not reported : Tinnituspremature labor, intrauterine death, fetal malformation, fetal growth retardation, fetal damage, carcinogenic effect on offspring [ Ref ]. Your doctor may recommend reliable contraception in order to prevent pregnancy while you're on this drug. Cancer Research. Are You Newly Diagnosed? What Is Multiple Myeloma? Note: Not all side effects are listed above. But you should always inform your health care provider if you experience any unusual symptoms. Retrieved 8 December As reported Ctoxan O. Request an Appointment Schedule an Cyotxan by calling Cyclophosphamide-induced AML, when it happens, typically presents some years after treatment, with incidence peaking around 3—9 years. Cybor-d can also be used at first or subsequent relapse. Pictured is a woman with microscopic polyangiitis treated with intravenous cyclophosphamide and high doses of corticosteroids. Intravenous IV Cytoxan can also be used as part of the stem cell harvesting process in combination with colony stimulating factors. Some side effects may not be reported. Bone marrow depression. Gentle exercise is encouraged such as a daily walk. Monitoring and Testing While Taking Cyclophosphamide You will be checked regularly by your doctor while you are taking cyclophosphamide, to monitor side effects and check your response to therapy. Published Dec Asta-Forschung und Therapie in German. Cyclophosphamide reduces plasma pseudocholinesterase activity and may result in prolonged neuromuscular blockade when administered concurrently with succinylcholine. Women may go through signs of menopause change of life like vaginal dryness or itching. The most common side effects of IV Cytoxan include: low blood counts hair loss nausea and vomiting loss of appetite loss of fertility discoloration of the skin or nails. Individuals should consult a qualified health care provider for professional medical advice, diagnosis and treatment of a medical or health condition. Browse Drugs and Medicines. Get plenty or rest. Contact your health Cytkxan provider within 24 hours of noticing any of the following:. Side effects that are very Cjtoxan - occurring in less than about 10 percent of patients - are not Cytoxan here. Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. A cup is 8 ounces of fluid. Blood Reviews. Related: Breast Cancer. Self-Care Tips Drink at least two to three quarts of fluid every 24 hours, unless you are instructed otherwise. Availability Discontinued. Allergic reactions shortness of breath, swelling of feet or ankles, rash, swollen throat Potential harm to a fetus Possible infertility Neutropenia low blood count that leads to a greater risk of infection Hair loss Nausea Vomiting Diarrhea Fatigue Irritation in the mouth Menstrual cycle interruptions Brittle nails. For the most part, the potential side—effects of cyclophosphamide differ from those of prednisone. Gan To Kagaku Ryoho. Barrier methods of contraception, such as condoms, are recommended for up to one year after last dose of cyclophosphamide. Onset: 7 days Nadir: days Recovery: 21 days Nadir: Meaning low point, nadir is the point in time between chemotherapy cycles in which you experience low blood counts. Take cyclophosphamide at around the same time every day. Note: If Cytxoan drug has been approved for one use, physicians may Cytoxan to use this same drug for other problems if they Cytoxann it may be helpful. Clinical Pharmacokinetics. Due to its toxicity, it is replaced as soon as possible by less toxic drugs. Namespaces Article Talk. Cytooxan from the original on 2 January National Cancer Institute Cutoxan In women, menstrual bleeding may become irregular or stop while you are getting this drug. Pulmonary injury appears rare,  but can present with two clinical patterns: an early, acute pneumonitis and a chronic, progressive fibrosis. If you're pregnant or become pregnant, talk to your doctor about alternatives to Cytoxan. INIST : Using these might affect your cancer or interfere with your treatment. European Journal of Clinical Investigation Review. What special precautions should I follow? The length of treatment depends on the types of drugs you are taking, how well your body responds to them, and the type of cancer or condition you have. Cyclophosphamide is used to treat cancers and autoimmune diseases. Women who are pregnant or breast-feeding should tell their doctors before they begin taking this drug. Cyclophosphamide-induced leukemia will often involve complex cytogeneticswhich carries a worse prognosis than de novo AML.
Cytoxan belongs to the drugs for treatment of cancer with cytotoxic effect. Its active substance cyclophosphamide is converted in the liver by cytochrome P450 into two active substances acrolein and phosphoramide. They are the active compounds, and they slow the growth of cancer cells inhibiting their proliferation and metabolism. First of all this effect concerns cells of uncontrolled growing but also damages other cells of the body resulting in serious side effects. Cytoxan also can be referred to as immunosuppressive agent. Cytoxan is used to treat malignant lymphoma (lymphocytic and gistiotsitarnaya lymphoma, lymphogranulomatosis, Burkitt lymphoma, lymphoma, mixed type), multiple myeloma, leukemias (lymphocytic leukemia, granulocytic leukemia, myelocytic leukemia, acute lymphoblastic leukemia in children), neuroblastoma, ovarian adenocarcinoma, retinoblastoma, breast carcinoma.
Dosage and direction
For adults and children Cytoxan is administered intravenously by 40-50 mg/kg over 3-5 days in divided doses. An oral dose of this medication is oral dose is 1-5 mg/kg daily. Dosage should be corrected on a basis of regular blood tests for white blood cell count. This medication can be taken orally also with or without food.
Carefulness should be exercised in patients with myelosuppression, liver or kidney disorders, with the previous radiation and chemotherapy. During treatment a regular monitoring of blood and urine count tests (for the presence of red blood cells) is required. In women of childbearing age a reliable contraception is recommended if Cytoxan is taken.
Hypersensitivity, severe myelosuppression.
Side effects of Cytoxan include vulnerability to infections, the development of a secondary cancer, typically of the bladder, lymph nodes, or bone marrow. A secondary cancer may occur several years after the drug is given.
Notify your doctor before to take anticancer drugs such as doxorubicin, allopurinol, and phenobarbital with Cytoxan. Correction of steroid hormones dosage should be done if they are taken with Cytoxan in patients with removed adrenal glands.
If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not take double or extra doses. Take your usually dose next day in the same regularly time.
Symptoms of Cytoxan overdose are not expected. If you suppose that took too much of it call your doctor immediately.
Store at room temperature between 20-25 C (68-77 F). Keep out of heat, moisture, sunlight, of the reach of children. Storage in a bathroom is not recommended.
We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. РђРїСѓ specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.